ML-252 hydrochloride

CAS: 2309887-61-2

Ref. TM-T85299

Produktinformation

• Name: ML-252 hydrochloride
• Marke: Targetmol
• Beschreibung: ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S)-enantiomer, which is significantly more effective than both its (R)-enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.

Chemische Eigenschaften

• Molekulargewicht: 344.9
• Formel: C₂₀H₂₄N₂OHCl
• Farbe/Form: Solid