PROTAC EGFR degrader 11

CAS: 3034244-71-5

Ref. TM-T88077

Produktinformation

• Name: PROTAC EGFR degrader 11
• Marke: Targetmol
• Beschreibung: PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.

Chemische Eigenschaften

• Molekulargewicht: 991.61
• Formel: C₄₉H₆₄ClFN₁₀O₇S
• Farbe/Form: Solid