PROTAC EGFR degrader 10

CAS: 3034244-56-6

Ref. TM-T88273

Produktinformation

• Name: PROTAC EGFR degrader 10
• Marke: Targetmol
• Beschreibung: PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.

Chemische Eigenschaften

• Molekulargewicht: 973.62
• Formel: C₄₉H₆₅ClN₁₀O₇S
• Farbe/Form: Solid