CHMFL-48

CAS: 2479290-65-6

Ref. TM-T89947

Produktinformation

• Name: CHMFL-48
• Marke: Targetmol
• Beschreibung: CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).

Chemische Eigenschaften

• Molekulargewicht: 573.61
• Formel: C₃₁H₃₀F₃N₇O
• Farbe/Form: Solid