Protosappanin A

CAS: 102036-28-2

Ref. TM-TJS1779

Produktinformation

• Name: Protosappanin A
• Synonyme: PTA, 3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one, 6H-Dibenz(b,d)oxocin-7(8H)-one, 3,10,11-trihydroxy-, Sappanol B
• CAS: 102036-28-2

Beschreibung

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 272.25
• Formel: C₁₅H₁₂O₅
• Reinheit: 100%
• Farbe/Form: Solid