BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)

Ref. TM-TMPH-02536

Produktinformation

• Name: BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)
• Synonyme: Bnip3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, Nip3

Beschreibung

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 23.8 kDa (predicted)
• Farbe/Form: Solid