Beclin-1 Protein, Mouse, Recombinant (His & SUMO)

Ref. TM-TMPH-02538

Produktinformation

• Name: Beclin-1 Protein, Mouse, Recombinant (His & SUMO)
• Synonyme: Beclin-1, GT197, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1

Beschreibung

Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis including endosome formation in neuronal cells. May play a role in antiviral host defense.; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 67.6 kDa (predicted)
• Farbe/Form: Solid