ACOD1 Protein, Mouse, Recombinant (His & Myc)

Ref. TM-TMPH-02585

Produktinformation

• Name: ACOD1 Protein, Mouse, Recombinant (His & Myc)
• Synonyme: Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, Aconitate decarboxylase, Aconitate decarboxylase 1, IRG1, Immune-responsive gene 1 protein, CAD

Beschreibung

Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 58.3 kDa (predicted)
• Farbe/Form: Solid