CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)

Ref. TM-TMPH-03267

Produktinformation

• Name: CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
• Synonyme: Clm1, Cd300lf, CD300 antigen-like family member F, CLM-1, CD300f, CMRF35-like molecule 1

Beschreibung

Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 38.3 kDa (predicted)
• Farbe/Form: Solid