CCL16 Protein, Human, Recombinant

Ref. TM-TMPJ-00018

Produktinformation

• Name: CCL16 Protein, Human, Recombinant
• Synonyme: NCC-4, Lymphocyte and Monocyte Chemoattractant, LMC, NCC4, HCC-4, ILINCK, Chemokine CC-4, LCC-1, CCL16, Monotactin-1, MTN-1, IL-10-Inducible Chemokine, C-C Motif Chemokine 16, Chemokine LEC, Small-Inducible Cytokine A16, SCYA16, Liver-Expressed Chemokine

Beschreibung

CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 14 KDa, reducing conditions
• Farbe/Form: Solid