EXTL2 Protein, Mouse, Recombinant (His)

Ref. TM-TMPJ-01317

Produktinformation

• Name: EXTL2 Protein, Mouse, Recombinant (His)
• Synonyme: EXT-related protein 2, α-1, Alpha-GalNAcT EXTL2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, α-GalNAcT EXTL2, Alpha-1, Extl2, Exostosin-like 2, Glucuronyl-galactosyl-proteoglycan 4-α-N-acetylglucosaminyltransferase, 4-N-acetylhexosaminyltransferase EXTL2

Beschreibung

Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 35 KDa (reducing condition)
• Farbe/Form: Solid