LAIR1 Protein, Human, Recombinant (His & Avi)

Ref. TM-TMPK-00177

Produktinformation

• Name: LAIR1 Protein, Human, Recombinant (His & Avi)
• Synonyme: CD305, LAIR1, LAIR-1, HLAIR1

Beschreibung

LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 18.2 kDa (predicted). Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.
• Farbe/Form: Solid