Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

Ref. TM-TMPK-01158

Produktinformation

• Name: Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)
• Synonyme: SCTE, KLKL2, KLK5, KLK-L2, Klnc, Kallikrein c

Beschreibung

The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 29.9 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
• Farbe/Form: Solid