FNDC4 Protein, Human, Recombinant (mFc)

Ref. TM-TMPY-00176

Produktinformation

• Name: FNDC4 Protein, Human, Recombinant (mFc)
• Synonyme: fibronectin type III domain containing 4, FRCP1

Beschreibung

FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. That FNDC4 may be a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 39.7 kDa (predicted)
• Farbe/Form: Solid