NT5C3A/NT5C3 Protein, Human, Recombinant

Ref. TM-TMPY-02893

Produktinformation

• Name: NT5C3A/NT5C3 Protein, Human, Recombinant
• Synonyme: UMPH1, UMPH, PSN1, POMP, PN-I, P5N-1, P5'N-1, P5N1, p36, NT5C3, hUMP1, cN-III
• Marke: Targetmol
• Beschreibung: NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but not of its catalytic mutants, suppressed IL-8 production by HEK293 cells. NT5C3A-stimulated sirtuin activity resulted in deacetylation of histone H3 and the NF-kappaB subunit RelA (also known as p65), both of which were associated with the proximal region of the Il8 promoter, thus repressing the transcription of Il8 Together.

Chemische Eigenschaften

• Molekulargewicht: 32.7kDa (predicted); 32 kDa (reducing conditions)
• Farbe/Form: Liquid