BOLA1 Protein, Human, Recombinant (His)

Ref. TM-TMPY-04022

Produktinformation

• Name: BOLA1 Protein, Human, Recombinant (His)
• Synonyme: CGI-143, bolA family member 1

Beschreibung

BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential. Furthermore, overexpression of BOLA1 nullifies the effect of BSO and S-nitrosocysteine on mitochondrial morphology. Conversely, knockdown of the BOLA1 gene increases the oxidation of mitochondrial thiol groups. Supporting a role of BOLA1 in controlling the mitochondrial thiol redox potential is that BOLA1 orthologs only occur in aerobic eukaryotes. A measured interaction of BOLA1with the mitochondrial monothiol glutaredoxin GLRX5 provides hints for potential mechanisms behind BOLA1's effect on mitochondrial redox potential.

• Marke: Targetmol

Chemische Eigenschaften

• Molekulargewicht: 16.4 kDa (predicted)
• Farbe/Form: Solid