Afatinib Dimaleate

CAS: 850140-73-7

Ref. TR-A355315

Produktinformation

• Name: Afatinib Dimaleate
• Synonyme: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide (2Z)-2-butenedioate (1:2) (9CI), BIBW 2992MA2, 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2), BIBW2992 DiMaleate, Bibw 2992Ma2, Bibw2992-Ma2

Beschreibung

Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.
References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 718.08
• Formel: C₂₄H₂₅ClFN₅O₃C₄H₄O₄
• Farbe/Form: Neat
• InChl: /m0../s1, 2*2-1-/t16-, 2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29), 2*1-2H,(H,5,6)(H,7,8)/b4-3+, , InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15