Akt Inhibitor XI

CAS: 902779-59-3

Ref. TR-A450500

Produktinformation

• Name: Akt Inhibitor XI
• Synonyme: (SP-4-3)-Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-κN2,κS]-copper, FPA-124

Beschreibung

Applications Akt inhibitor XI inhibits Akt in various cancer cells. Protein kinase B (PKB or Akt) is a serene/threonine kinase, which is involved in a wide variety of cellular processes including metabolism, apoptosis and cell proliferation. Furthermore, Akt inhibitor XI was employed in a biological study that aimed to develop a novel coiled-coil three-hybrid system that can identify potential allosteric inhibitors.
References Dan, S., et al.: Cancer Res. 70, 4982 (2010); Jester, B. W., et al.: J. Am. Chem. Soc. 132, 11727 (2010); Jester, B. W., et al.: J. Med. Chem. 55, 1526 (2012); Fedichev, P. O. and Vinnik, A. A. PCT Int. Appl. WO 2013147649 A2 20131003 (2013)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 381.73
• Formel: C₁₁H₉Cl₂CuN₃O₂S
• Farbe/Form: Green Solid
• SMILES: Cl.N=C([S-])N/N=C\c1coc2ccccc2c1=O.[Cl-].[Cu+2]