17-(Allylamino-d5) Geldanamycin

CAS: 75747-14-7

Ref. TR-A549652

Produktinformation

• Name: 17-(Allylamino-d5) Geldanamycin
• Synonyme: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin, 17-(Allylamino-d5)-17-demethoxygeldanamycin, 17-(Allylamino-d5)-17-desmethylgeldanamycin, 17-Demethoxy-17-(allylamino-d5)geldanamycin, 17AAG-d5, CP 127374-d5, KOS 953-d5, NSC 330507-d5, Tanespimycin-d5
• Marke: TRC

Beschreibung

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

Chemische Eigenschaften

• Molekulargewicht: 590.719
• Formel: C₃₁D₅H₃₈N₃O₈
• Farbe/Form: Neat
• InChl: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1/i1D2,8D,12D2
• InChI Key: InChIKey=AYUNIORJHRXIBJ-RDXCHMSBSA-N
• SMILES: [2H]C([2H])=C([2H])C([2H])([2H])NC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O