Aloisine A RP107

CAS: 496864-16-5

Ref. TR-A575450

Produktinformation

• Name: Aloisine A RP107
• Synonyme: 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
• Marke: TRC
• Beschreibung: Applications A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).References Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),

Chemische Eigenschaften

• Molekulargewicht: 267.33
• Formel: C₁₆H₁₇N₃O
• Farbe/Form: Neat
• InChl: InChI=1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChI Key: InChIKey=PRIGRJPRGZCFAS-UHFFFAOYSA-N
• SMILES: CCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12