Ambrisentan Methyl Ester

CAS: 1106685-61-3

Ref. TR-A575871

Produktinformation

• Name: Ambrisentan Methyl Ester
• Synonyme: (+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic Acid Methyl Ester, (S)-Methyl 2-((4,6-Dimethylpyrimidin-2-yl)-oxy)-3-methoxy-3,3-diphenylpropanoate, (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate, (alphaS)-alpha-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenylbenzenepropanoic acid methyl ester

Beschreibung

Applications (S)-Methyl 2-((4,6-dimethylpyrimidin-2-yl)-oxy)-3-methoxy-3,3-diphenylpropanoate is a useful intermediate in the preparation of Ambrisentan. Ambrisentan is an Antihypertensive. Ambrisentan Impurity (A575860).
References Peng, X., et al.: J. Org. Chem., 77, 701 (2012), Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 392.45
• Formel: C₂₃H₂₄N₂O₄
• Farbe/Form: Off-White
• InChl: InChI=1S/C23H24N2O4/c1-16-15-17(2)25-22(24-16)29-20(21(26)27-3)23(28-4,18-11-7-5-8-12-18)19-13-9-6-10-14-19/h5-15,20H,1-4H3/t20-/m1/s1
• InChI Key: InChIKey=RCOLWOXJIUGEGI-HXUWFJFHSA-N
• SMILES: COC(=O)[C@@H](Oc1nc(C)cc(C)n1)C(OC)(c1ccccc1)c1ccccc1