Am 580

CAS: 102121-60-8

Ref. TR-A575880

Produktinformation

• Name: Am 580
• Synonyme: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-benzoic Acid, CD 336, NSC 608001, Ro 40-6055, 4-((5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Carbonyl)Aminobenz, 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid, 4-{[(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Carbonyl]Amino}Benzoic Acid, Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-, Benzoicacid,4-((5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Carbony, Cd 336, Cd336, L)Amino-, Ro40-6055

Beschreibung

Applications AM580 is a retinoic acid receptor agonist. It inhibits the proliferation of various tumor cells, by inhibiting survival signaling pathways and inducing apoptosis.
References Bernard, B., et al.: Biochem. Biophys. Res. Commun., 186, 977 (1992); Lu, Y., et al.: Oncogene, 29, 3665 (2010); Cheng, Y., et al.: J. Mol. Endocrinol., 46, 139 (2011)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 351.439
• Formel: C₂₂H₂₅NO₃
• Farbe/Form: White to Off-White Solid
• InChl: InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
• InChI Key: InChIKey=SZWKGOZKRMMLAJ-UHFFFAOYSA-N
• SMILES: CC1(C)CCC(C)(C)c2cc(C(=O)Nc3ccc(C(=O)O)cc3)ccc21