N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-α-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide

CAS: 1140251-30-4

Ref. TR-A601720

Produktinformation

• Name: N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-α-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide
• Synonyme: N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-a-D-arabinopyranosyl)amino]-5-pyrimidinyl]formamide

Beschreibung

Stability Air and Moisture Sensitive
Applications N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-α-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide is a clofarabine related compound. Clofarabine (C586890) is a second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 321.69
• Formel: C₁₀H₁₃ClFN₅O₄
• Farbe/Form: Neat
• InChl: InChI=1S/C10H13ClFN5O4/c11-10-15-7(13)5(14-2-18)8(17-10)16-9-4(12)6(20)3(19)1-21-9/h2-4,6,9,19-20H,1H2,(H,14,18)(H3,13,15,16,17)/t3-,4+,6-,9+/m1/s1
• InChI Key: InChIKey=GIFVSTNLGMIVGT-AQZRFWRFSA-N
• SMILES: Nc1nc(Cl)nc(N[C@H]2OC[C@@H](O)[C@@H](O)[C@@H]2F)c1NC=O