(2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one

CAS: 115992-91-1

Ref. TR-A609220

Produktinformation

• Name: (2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one
• Synonyme: N,N-Didesmethyl-O-desmethyl-O'-desacetyl Diltiazem, (2S-cis)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one

Beschreibung

Applications (2S,3S)-5-(2-Aminoethyl)-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one is an impurity of diltiazem (D460620). Diltiazem Hydrochloride is a calcium channel blocker with vasodilating activity. Anti-anginal; anti-hypertensive; anti-arrhythmic (class IV).
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 330.4
• Formel: C₁₇H₁₈N₂O₃S
• Farbe/Form: Neat
• InChl: InChI=1S/C17H18N2O3S/c18-9-10-19-13-3-1-2-4-14(13)23-16(15(21)17(19)22)11-5-7-12(20)8-6-11/h1-8,15-16,20-21H,9-10,18H2/t15-,16+/m1/s1
• InChI Key: InChIKey=NIQVIAXYLUEION-CVEARBPZSA-N
• SMILES: NCCN1C(=O)[C@H](O)[C@H](c2ccc(O)cc2)Sc2ccccc21