(3S,4S,5R)-6-(6-Amino-2-chloro-9H-purin-9-yl)-5-fluorotetrahydro-2H-pyran-3,4-diol

Ref. TR-A609345

Produktinformation

• Name: (3S,4S,5R)-6-(6-Amino-2-chloro-9H-purin-9-yl)-5-fluorotetrahydro-2H-pyran-3,4-diol
• Synonyme: (3S,4S,5R)-6-(6-amino-2-chloropurin-9-yl)-5-fluorooxane-3,4-diol

Beschreibung

Applications (3S,4S,5R)-6-(6-Amino-2-chloro-9H-purin-9-yl)-5-fluorotetrahydro-2H-pyran-3,4-diol is an impurity of Clofarabine (C586890), Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 303.677
• Formel: C₁₀H₁₁ClFN₅O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(18)1-20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9?/m0/s1
• InChI Key: InChIKey=LJMSCYWKPGTRPF-MPWJDEBYSA-N
• SMILES: Nc1nc(Cl)nc2c1ncn2C1OC[C@H](O)[C@H](O)[C@H]1F