6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

CAS: 545380-34-5

Ref. TR-A621350

Produktinformation

• Name: 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
• Synonyme: N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine, QNZ, 4,6-quinazolinediamine, N~4~-[2-(4-phenoxyphenyl)ethyl]-
• CAS: 545380-34-5

Beschreibung

Applications QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
References Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 356.42
• Formel: C₂₂H₂₀N₄O
• Farbe/Form: Light Beige to Dark Yellow Solid
• InChl: InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
• InChI Key: InChIKey=IBAKVEUZKHOWNG-UHFFFAOYSA-N
• SMILES: Nc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1