(5S)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Di-p-anisoyl-l-tartaric Acid Salt

CAS: 1260774-47-7

Ref. TR-A622636

Produktinformation

• Name: (5S)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Di-p-anisoyl-l-tartaric Acid Salt
• Synonyme: (S)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (2R,3R)-2,3-bis((4-methoxybenzoyl)oxy)succinate

Beschreibung

Applications (5S)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Di-p-anisoyl-l-tartaric Acid Salt is an intermediate in the synthesis of Dextrosimendan (D299550), an isomer and impurity of Levosimendan (L378000), a bioactive enantiomer of Simendan (S466000). Levosimendan is a positive inotropic agent with vasodilating activity.
References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 203.24 + 418.35
• Formel: C₁₁H₁₃N₃O•C₂₀H₁₈O₁₀
• Farbe/Form: Neat
• InChl: InChI=1S/C20H18O10.C11H13N3O/c1-27-13-7-3-11(4-8-13)19(25)29-15(17(21)22)16(18(23)24)30-20(26)12-5-9-14(28-2)10-6-12;1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h3-10,15-16H,1-2H3,(H,21,22)(H,23,24);2-5,7H,6,12H2,1H3,(H,13,15)/t15-,16-;7-/m10/s1
• InChI Key: InChIKey=KHWPQCAEYTVUOQ-HTYPNKEUSA-N
• SMILES: COc1ccc(C(=O)O[C@@H](C(=O)O)[C@@H](OC(=O)c2ccc(OC)cc2)C(=O)O)cc1.C[C@H]1CC(=O)NN=C1c1ccc(N)cc1