(3S)-Aminoquinuclidine

CAS: 120570-05-0

Ref. TR-A628775

Produktinformation

• Name: (3S)-Aminoquinuclidine
• Synonyme: (S)-1-Azabicyclo[2.2.2]oct-3-ylamine, (S)-3-Amino-1-azabicyclo[2.2.2]octane, (S)-3-Aminoquinuclidine, (S)-Quinuclidin-3-amine, (S)-(-)-3-Aminoquinuclidine, (3S)-1-Azabicyclo[2.2.2]octan-3-amine, (S)-1-Azabicyclo[2.2.2]octan-3-amine, (3S)-1-Azabicyclo[2.2.2]octan-3-amine, (3S)-Quinuclidin-3-amine, 1-Azabicyclo[2.2.2]octan-3-amine, (3S)-, T66 A B CNTJ AZ & & S Form

Beschreibung

Applications (3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 126.2
• Formel: C₇H₁₄N₂
• Farbe/Form: Neat
• InChl: InChI=1S/C7H14N2/c8-7-5-9-3-1-6(7)2-4-9/h6-7H,1-5,8H2/t7-/m1/s1
• InChI Key: InChIKey=REUAXQZIRFXQML-SSDOTTSWSA-N
• SMILES: N[C@@H]1CN2CCC1CC2