(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride

CAS: 1204818-19-8

Ref. TR-A630750

Produktinformation

• Name: (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride
• Synonyme: Benzenebutanoic acid, beta-amino-2,4,5-trifluoro-, hydrochloride (1:1), (betaR)-, (3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride, Sitagliptin Impurity 17
• CAS: 1204818-19-8

Beschreibung

Stability Hygroscopic
Applications (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor.
References Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010); Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 269.65
• Formel: C₁₀H₁₀F₃NO₂·ClH
• Farbe/Form: Neat
• InChl: InChI=1S/C10H10F3NO2.ClH/c11-7-4-9(13)8(12)2-5(7)1-6(14)3-10(15)16;/h2,4,6H,1,3,14H2,(H,15,16);1H/t6-;/m1./s1
• InChI Key: InChIKey=FZHZEWNJQKHBTG-FYZOBXCZSA-N
• SMILES: Cl.N[C@@H](CC(=O)O)Cc1cc(F)c(F)cc1F