3-Aminopiperidine-2,6-dione Hydrochloride

CAS: 24666-56-6

Ref. TR-A632980

Produktinformation

• Name: 3-Aminopiperidine-2,6-dione Hydrochloride
• Synonyme: 3-Amino-2,6-piperidinedione Monohydrochloride, 2-Amino-glutarimide Hydrochloride, 3-Amino-2,6-dioxopiperidine Hydrochloride, 3-Amino-2,6-piperidinedione Hydrochloride, 3-Aminopiperidine-2,6-dione Monohydrochloride, DL-Glutamic Acid Imide Hydrochloride, Glutamimide Hydrochloride, 2,6-Dioxopiperidine-3-ammonium chloride, 3-Aminopiperidine-2,6-Dione Hydrochloride (1:1), 2,6-Piperidinedione,3-amino-,hydrochloride, 3-Aminopiperidine-2,6-dione hydrochloride, 2,6-Piperidinedione, 3-amino-, monohydrochloride, (+-)-, (+-)-3-Amino-2,6-piperidinedione monohydrochloride, Glutamic acid imide-DL-hydrochloride, 3-Amino-2,6-dioxo-piperidine hydrochloride, 3-Amino Piperdine-2,6-Dion Hydrochloride

Beschreibung

Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 164.590
• Formel: C₅H₈N₂O₂·ClH
• Farbe/Form: Off-White
• InChl: InChI=1S/C5H8N2O2.ClH/c6-3-1-2-4(8)7-5(3)9;/h3H,1-2,6H2,(H,7,8,9);1H/t3-;/m0./s1
• InChI Key: InChIKey=YCPULGHBTPQLRH-UHFFFAOYSA-N
• SMILES: Cl.NC1CCC(=O)NC1=O