Amonafide

CAS: 69408-81-7

Ref. TR-A634205

Produktinformation

• Name: Amonafide
• Synonyme: 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, FA 142, M-FA 142, MADE-FA 142, NCI 308847, NSC 308847, Nafidimide, 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-, 5-amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, Benzisoquinolinedione, Fa 142, M-Fa 142, Made-Fa 142, Nci 308847
• CAS: 69408-81-7

Beschreibung

Applications Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent.
References Hsiang, Y., et al.: Mol. Pharmacol., 36, 371 (1989), Costanza, M., et al.: Clin. Cancer Res., 1, 699 (1995), Innocenti, F., et al.: Drug Metab. Dispos., 29, 596 (2001), Brana, M., et al.: J. Med. Chem., 47, 1391 (2004),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 283.33
• Formel: C₁₆H₁₇N₃O₂
• Farbe/Form: Yellow to Dark Yellow Solid
• InChl: InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
• InChI Key: InChIKey=UPALIKSFLSVKIS-UHFFFAOYSA-N
• SMILES: CN(C)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O