1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone

CAS: 1267610-26-3

Ref. TR-A637898

Produktinformation

• Name: 1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone
• Synonyme: 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone, 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one, 2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-, Apixaba inretmediate A

Beschreibung

Applications 1-​(4-​Aminophenyl)​-​5,​6-​dihydro-​3-​(4-​morpholinyl)​-​2(1H)​-​pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 273.33
• Formel: C₁₅H₁₉N₃O₂
• Farbe/Form: Neat
• InChl: InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
• InChI Key: InChIKey=YUGIGSPFTMLIMA-UHFFFAOYSA-N
• SMILES: Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1