Arginine Vasopressin Diacetate

CAS: 75499-44-4

Ref. TR-A769550

Produktinformation

• Name: Arginine Vasopressin Diacetate
• Synonyme: 19-Amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide Diacetate, 3-(Phenylalanine)-8-arginineoxytocin, 8-L-Arginine-vasopressin Diacetate, AVP Diacetate, Arg8-vasopressin Diacetate, Arginine antidiuretic hormone Diacetate, Arginine-8-vasopressin Diacetate, Argipressin Diacetate, Leiormone Diacetate, [8-Arginine]vasopressin Diacetate, 3-(L-Phenylalanine)-8-L-arginine-oxytocin Diacetate, Pitressin Diacetate, Rindervasopressin Diacetate, L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide Cyclic (1?6)-Disulfide Diacetate

Beschreibung

Applications An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.
References Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 1204.34
• Formel: C₅₀H₇₃N₁₅O₁₆S₂
• Farbe/Form: Neat
• InChl: InChI=1S/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29+,30+,31-,32+,33+,34-;/m0./s1
• InChI Key: InChIKey=ZHFGXNMADRRGQP-NQHFENJBSA-N
• SMILES: CC(=O)O.N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O