Produktinformation
- (R)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide
- Arimoclomol [INN]
- Arimoclomolum
- Arimoclomolum [INN-Latin]
- Brx 345
- N-((2R)-2-Hydroxy-3-(1-piperidyl)propoxy)pyridine-3-carboximidoyl chloride, 1-oxide
- Unii-Eut3557Rt5
- 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide
- N-{[(2R)-2-hydroxy-3-(piperidin-1-yl)propyl]oxy}pyridine-3-carboximidoyl chloride 1-oxide
- BRX 345 free base
- Mehr Synonyme anzeigen
Stability Hygroscopic
Applications Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
References Kieran, Dairin., et al.: Nature Medicine., 10, 402 (2004); Brown, Ian R., et al.: Ann N Y Acad Sci., 1113, 147 (2007); Traynor, B. J., et al.: Neurology., 67, 20 (2006),