Atorvastatin Epoxy Pyrrolooxazin Tricyclo Methane
Ref. TR-A791803
1mg | Ausgelaufen | ||
500µg | Ausgelaufen | ||
2500µg | Ausgelaufen |
Produktinformation
- Methyl 2-(9-(4-Fluorophenyl)-1b-isopropyl-9a-phenyl-1a-(phenylcarbamoyl)octahydro-1aH-5,9-epoxyoxireno[2',3':3,4]pyrrolo[2,1-b][1,3]oxazocin-3-yl)acetate
Applications Atorvastatin Epoxy Pyrrolooxazin Tricyclo Methane is an intermediate in the synthesis of Atorvastatin Epoxy Pyrrolooxazin Tricyclic Potassium Salt (A791895), a photodegadation product of Atorvastatin (a cyclic impurity of Atorvastatin (A791750)), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),