Atractyloside Calcium Salt

CAS: 772298-35-8

Ref. TR-A794540

Produktinformation

• Name: Atractyloside Calcium Salt
• Synonyme: (2ß,15a)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-ß-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt, 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt

Beschreibung

Stability Hygroscopic
Applications Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Qin, Z.H. et al.: J. Biol. Chem., 276, 8079 (2001); Chang, N.S. et al.: J. Biol. Chem., 276, 3361 (2001); Ziegler, M. et al.: J. Biol. Chem., 268, 25320 (1993); Marzo, I. et al.: Science, 281, 2027 (2027); Vieira, H.L. et al.: Cell Death Differ., 7, 1146 (2000);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 783.9
• Formel: C₃₀H₄₃Ca₁·5O₁₆S₂
• Farbe/Form: Neat
• InChl: InChI=1S/C30H46O16S2/c1-14(2)9-22(32)44-25-24(46-48(39,40)41)23(45-47(36,37)38)20(13-31)43-28(25)42-17-10-18(27(34)35)19-7-8-30-11-16(15(3)26(30)33)5-6-21(30)29(19,4)12-17/h14,16-21,23-26,28,31,33H,3,5-13H2,1-2,4H3,(H,34,35)(H,36,37,38)(H,39,40,41)/p-3/t16-,17-,18-,19-,20?,21+,23-,24-,25?,26+,28-,29-,30-/m1/s1
• InChI Key: InChIKey=FYQXODZRNSCOTR-HRFUWPIYSA-K
• SMILES: C=C1[C@H](O)[C@@]23CC[C@@H]4[C@H](C(=O)[O-])C[C@@H](O[C@@H]5OC(CO)[C@@H](OS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])C5OC(=O)CC(C)C)C[C@@]4(C)[C@@H]2CC[C@@H]1C3