Bacitracin F (~75%)

CAS: 22601-63-4

Ref. TR-B106530

Produktinformation

• Name: Bacitracin F (~75%)
• Synonyme: L-Asparagine, N-[[2-[(2S)-2-methyl-1-oxobutyl]-4-thiazolyl]carbonyl]-L-leucyl-D-a-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-a-aspartyl-, (10?4)-lactam, Bacitracin F (8CI,9CI), 1,4,7,10,13,16,19-Heptaazacyclopentacosane, cyclic peptide deriv., 4,10-Anhydro[N-[[2-[(2S)-2-methyl-1-oxobutyl]-1,3-thiazol-4-yl]carbonyl]-L-leucyl-D-a-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-a-aspartyl-L-asparagine]

Beschreibung

Applications Bacitracin F is a major Bacitracin (B106500) analog, a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI).
References Freedman, R., et al.: Cell, 57, 1069 (1989); Noiva, R., et al.: J. Biol. Chem., 267, 3553 (1992); Ikai, Y., et al.: J. Antibiot., 48, 233 (1995); Lovat, P., et al.: Cancer Res., 68, 5363 (2008); Byrne, L., et al.: Biochem. J., 423, 209 (2009); Dickerhof, N., et al.: FEBS J., 278, 2034 (2011)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 1419.65
• Formel: C₆₆H₉₈N₁₆O₁₇S
• Reinheit: ~75%
• Farbe/Form: Neat
• InChl: InChI=1S/C66H98N16O17S/c1-9-35(6)52(82-58(92)42(22-23-50(84)85)73-59(93)43(26-34(4)5)75-63(97)48-32-100-66(80-48)54(88)37(8)11-3)64(98)74-40-20-15-16-25-70-55(89)46(29-49(68)83)77-62(96)47(30-51(86)87)78-61(95)45(28-39-31-69-33-71-39)76-60(94)44(27-38-18-13-12-14-19-38)79-65(99)53(36(7)10-2)81-57(91)41(21-17-24-67)72-56(40)90/h12-14,18-19,31-37,40-47,52-53H,9-11,15-17,20-30,67H2,1-8H3,(H2,68,83)(H,69,71)(H,70,89)(H,72,90)(H,73,93)(H,74,98)(H,75,97)(H,76,94)(H,77,96)(H,78,95)(H,79,99)(H,81,91)(H,82,92)(H,84,85)(H,86,87)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,52-,53-/m0/s1
• InChI Key: InChIKey=CZWAYUVQAPZALN-NTUKFPLLSA-N
• SMILES: CC[C@@H](C)C(=O)c1ncc(C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)NC(C(=O)N[C@H]2CCCCNC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H](CCCN)NC2=O)[C@H](C)CC)s1