3’-O-Benzyl Sofosbuvir Desphosphate

Ref. TR-B289670

Produktinformation

• Name: 3’-O-Benzyl Sofosbuvir Desphosphate
• Synonyme: 1-((2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Beschreibung

Applications 3’-O-Benzyl Sofosbuvir Desphosphate may be a metabolite of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 350.35
• Formel: C₁₇H₁₉FN₂O₅
• Farbe/Form: Neat
• InChl: InChI=1S/C17H19FN2O5/c1-17(18)14(24-10-11-5-3-2-4-6-11)12(9-21)25-15(17)20-8-7-13(22)19-16(20)23/h2-8,12,14-15,21H,9-10H2,1H3,(H,19,22,23)/t12-,14?,15-,17?/m1/s1