Bicalutamide

CAS: 90357-06-5

Ref. TR-B382000

Produktinformation

• Name: Bicalutamide
• Synonyme: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, Casodex, Cosudex, ICI 176334, ZD 176334, (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, (+/-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide, (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, (±)-4′-Cyano-α,α,α-trifluoro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide, 4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline, Bicalutamide (Subject to patent free), Casode, Ici 176334, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamid, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, Zd 176334, [(4- Fluorophenyl) Sulfonyl]-2-Hydroxy- 2-Methyl Propanamide

Beschreibung

Applications Non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal); Non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation.
References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 430.37
• Formel: C₁₈H₁₄F₄N₂O₄S
• Farbe/Form: White
• InChl: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
• SMILES: CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1