N-Biotinylaminoethyl Methanethiosulfonate

CAS: 162758-04-5

Ref. TR-B394750

Produktinformation

• Name: N-Biotinylaminoethyl Methanethiosulfonate
• Synonyme: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(2-methylsulfonylsulfanylethyl)pentanamide

Beschreibung

Stability Moisture Sensitive
Applications Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. MTSEA-biotin has recently been used to probe the topology of the serotonin (5-HT) transporter by site-directed chemical labelling.
References J. Biol. Chem., 273(20), 12675 (1998), Adams, C.M., et al.: J. Biol. Chem., 273 (46), 30204 (1998), Boileau, A. J., et al.: J. Neurosci., 19, 12, 4847 (1999), Wagner, D.A.and Czajkowski, C.: J. Neurosci., 21, 67 (2001), Traebert, M.: J. Membr. Biol., 180, 83 (2001)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 381.53
• Formel: C₁₃H₂₃N₃O₄S₃
• Farbe/Form: Neat
• InChl: InChI=1S/C13H23N3O4S3/c1-23(19,20)22-7-6-14-11(17)5-3-2-4-10-12-9(8-21-10)15-13(18)16-12/h9-10,12H,2-8H2,1H3,(H,14,17)(H2,15,16,18)/t9-,10-,12-/m0/s1
• InChI Key: InChIKey=CQPWMXNDGWWWHG-NHCYSSNCSA-N
• SMILES: CS(=O)(=O)SCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12