5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine

CAS: 81246-83-5

Ref. TR-B415160

Produktinformation

• Name: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine
• Synonyme: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Beschreibung

Applications 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine is used to prepare ppGpp analogs as inhibitors of RelA from Gram-negative/-positive bacteria. It is also used to synthesize guanosine 5'-conjugates as initiator molecules for transcription priming.
References Wexselblatt, E., et al.: Bioorg. Med. Chem., 18, 4485 (2010); Wolf, J., et al.:Org. Biomol. Chem., 6, 899 (2008)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 655.697
• Formel: C₃₅H₃₇N₅O₈
• Farbe/Form: Neat
• InChl: InChI=1S/C35H37N5O8/c1-20(2)31(43)38-34-37-30-27(32(44)39-34)36-19-40(30)33-29(42)28(41)26(48-33)18-47-35(21-8-6-5-7-9-21,22-10-14-24(45-3)15-11-22)23-12-16-25(46-4)17-13-23/h5-17,19-20,26,28-29,33,41-42H,18H2,1-4H3,(H2,37,38,39,43,44)/t26-,28-,29-,33-/m1/s1