1,3-Bis(2-chloroethyl)urea

CAS: 2214-72-4

Ref. TR-B419015

Produktinformation

• Name: 1,3-Bis(2-chloroethyl)urea
• Synonyme: Urea, N,N'-bis(2-chloroethyl)-, Urea, 1,3-bis(2-chloroethyl)- (6CI,7CI,8CI), NSC 36198
• Marke: TRC
• Beschreibung: Stability Hygroscopic, Unstable in SolutionApplications 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),

Chemische Eigenschaften

• Molekulargewicht: 185.05
• Formel: C₅H₁₀Cl₂N₂O
• Farbe/Form: Neat
• InChl: InChI=1S/C5H10Cl2N2O/c6-1-3-8-5(10)9-4-2-7/h1-4H2,(H2,8,9,10)
• InChI Key: InChIKey=VBWBRZHAGLZNST-UHFFFAOYSA-N
• SMILES: O=C(NCCCl)NCCCl