3,4-Bis(difluoromethoxy)benzaldehyde

CAS: 127842-54-0

Ref. TR-B426290

Produktinformation

• Name: 3,4-Bis(difluoromethoxy)benzaldehyde
• Synonyme: 3,4-Bis-difluoromethoxybenzaldehyde

Beschreibung

Applications 3,4-Bis(difluoromethoxy)benzaldehyde is an impurity of the antiasthmatic drug Roflumilast (R639700). 3,4-Bis(difluoromethoxy)benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders.
References Bender, A., et al.: Pharmacol. Rev., 58, 488 (2006), Huang, Z., et al.: Curr. Med. Chem., 13, 3253 (2006), Lerner, A., et al.: Biochem. J., 393, 21 (2006),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 238.14
• Formel: C₉H₆F₄O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C9H6F4O3/c10-8(11)15-6-2-1-5(4-14)3-7(6)16-9(12)13/h1-4,8-9H
• InChI Key: InChIKey=IPHURZAZBKLMQJ-UHFFFAOYSA-N
• SMILES: O=Cc1ccc(OC(F)F)c(OC(F)F)c1