tert-Butylsulfinamide

CAS: 146374-27-8

Ref. TR-B693900

Produktinformation

• Name: tert-Butylsulfinamide
• Synonyme: 1,1-Dimethylethylsulfinamide, 2-Methyl-2-propanesulfinamide, 2-Methylpropan-2-sulfinamide, 2-Methyl-2-propanesulfinamide, 2-Methyl-2-Propanesulfinamide, 2-Methyl-2-Propanesulfinamide, Racemic, 2-Methyl-Propane-2-Sulfinic Acid Amide, 2-Methylpropane-1-Sulfinamide, 2-Propanesulfinamide, 2-methyl-, Racemic Tert Butylsulfinamide, T-Butylsulfinamide, Tert-Butylsulfinamide, Tert-Butylsulphinamide, tert-Butanesulfinamide

Beschreibung

Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.
References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 121.2
• Formel: C₄H₁₁NOS
• Farbe/Form: Neat
• InChl: InChI=1S/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3
• InChI Key: InChIKey=CESUXLKAADQNTB-UHFFFAOYSA-N
• SMILES: CC(C)(C)S(N)=O