2-tert-Butyldimethylsilyloxyethyl Tosylate

CAS: 148400-72-0

Ref. TR-B809836

Produktinformation

• Name: 2-tert-Butyldimethylsilyloxyethyl Tosylate
• Synonyme: 2-[tert-butyl(dimethyl)silyl]oxyethyl 4-methylbenzenesulfonate

Beschreibung

Applications 2-tert-Butyldimethylsilyloxyethyl Tosylate is an intermediate in the synthesis of Everolimus (E945400), which is Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 330.515
• Formel: C₁₅H₂₆O₄SSi
• Farbe/Form: Neat
• InChl: InChI=1S/C15H26O4SSi/c1-13-7-9-14(10-8-13)20(16,17)18-11-12-19-21(5,6)15(2,3)4/h7-10H,11-12H2,1-6H3
• InChI Key: InChIKey=SURVAMFPFPDSHK-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)OCCO[Si](C)(C)C(C)(C)C)cc1