Cabozantinib N-oxide

CAS: 1621681-63-7

Ref. TR-C051600

Produktinformation

• Name: Cabozantinib N-oxide
• Synonyme: N-[4-[(6,7-Dimethoxy-1-oxido-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Beschreibung

Applications Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.
References Jaeger, S., et al.: Cancer Res, 77, 459-469 (2017)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 517.51
• Formel: C₂₈H₂₄FN₃O₆
• Farbe/Form: Off-White
• InChl: InChI=1S/C28H24FN3O6/c1-36-24-15-21-22(16-25(24)37-2)32(35)14-11-23(21)38-20-9-7-19(8-10-20)31-27(34)28(12-13-28)26(33)30-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33)(H,31,34)
• InChI Key: InChIKey=FKJJTKYQXXLFPS-UHFFFAOYSA-N
• SMILES: COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)cc[n+]([O-])c2cc1OC