Carfilzomib-d8

CAS: 1537187-53-3

Ref. TR-C183462

Produktinformation

• Name: Carfilzomib-d8
• Synonyme: (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[[2-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)acetyl]amino]-4-phenylbutanoyl]amino]pentanamide

Beschreibung

Applications Carfilzomib-d8, is the labeled analogue of Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 727.959
• Formel: C₄₀D₈H₄₉N₅O₇
• Farbe/Form: Neat
• InChl: InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32+,33+,34+,40-/m1/s1/i18D2,19D2,20D2,21D2
• InChI Key: InChIKey=BLMPQMFVWMYDKT-KWMHNUBUSA-N
• SMILES: [2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CC(=O)N[C@H](CCc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]2(C)CO2)C1([2H])[2H]