2-Chloro-6-methoxy-4-methylquinoline

CAS: 6340-55-2

Ref. TR-C370060

Produktinformation

• Name: 2-Chloro-6-methoxy-4-methylquinoline
• Synonyme: 2-Chloro-4-methyl-6-methoxyquinoline, NSC 13577, NSC 51245, 2-hloro-6-methoxy-lepidine
• Marke: TRC
• Beschreibung: Applications 2-Chloro-6-methoxy-4-methylquinoline is an intermediate in the synthesis of Tafenoquine-d3 Succinate which is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.References McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989)

Chemische Eigenschaften

• Molekulargewicht: 207.66
• Formel: C₁₁H₁₀ClNO
• Farbe/Form: Neat
• InChl: InChI=1S/C27H40N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h14-15,17-18,21-22,28H,5-13,16H2,1-4H3,(H,31,32);1H/t17-,21+,22-;/m0./s1
• InChI Key: InChIKey=UTHZRYWNZSWSDS-RDZNBAMBSA-N
• SMILES: CCOC(=O)[C@@H](CCC1CCCCC1)N[C@@H](C)C(=O)N1Cc2cc(OC)c(OC)cc2C[C@H]1C(=O)O.Cl