2-Chloro-5-nitro-N-4-phenylbenzamide

CAS: 22978-25-2

Ref. TR-C374050

Produktinformation

• Name: 2-Chloro-5-nitro-N-4-phenylbenzamide
• Synonyme: GW 9662
• Marke: TRC

Beschreibung

Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb
References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)

Chemische Eigenschaften

• Molekulargewicht: 276.68
• Formel: C₁₃H₉ClN₂O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
• SMILES: O=C(Nc1ccccc1)c1cc([N+](=O)[O-])ccc1Cl