5-Chloro-3,3’-diiodo-L-thyronine

Ref. TR-C375205

Produktinformation

• Name: 5-Chloro-3,3’-diiodo-L-thyronine
• Synonyme: (2S)-2-amino-3-[3-chloro-4-(4-hydroxy-3-iodophenoxy)-5-iodophenyl]propanoic acid

Beschreibung

Applications 5-Chloro-3,3’-diiodo-L-thyronine is an impurity or analog of 3,3’,5-Triiodo-L-thyronine (T795350), which is a thyroid hormone derived from deiodination of prohormone thyroxine. Patients with diabetes mellitus (DM) are often associated with thyroid hormone abnormalities.
References Moura, N. A., et al.: Endocrine 51, 63 (2016); Block, P.: J. Med. Chem., 19(8), 1067-1069 (1976); Shiba, T., & Cahmann, H.J.: J.O.C., 29, 1652-1653 (1964)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 559.522
• Formel: C₁₅H₁₂ClI₂NO₄
• Farbe/Form: Neat
• InChl: InChI=1S/C15H12ClI2NO4/c16-9-3-7(5-12(19)15(21)22)4-11(18)14(9)23-8-1-2-13(20)10(17)6-8/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChI Key: InChIKey=XMIOSMPVSZVLDZ-LBPRGKRZSA-N
• SMILES: N[C@@H](Cc1cc(Cl)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O